An Easy Access to Construct Some Fused 1, 2, 4‐Triazines with Ring Junction Nitrogen Systems and Their Biological Evaluation. (9th February 2016) - Hamama, Wafaa S.
Abstract : The chemical reactivity of 4‐amino‐6‐benzyl‐3‐mercapto‐1, 2, 4‐triazine‐5(4 H )‐one (1 ) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1, 3, 4‐thiadiazoles4, 5, 6, which incorporating 1, 2, 4‐triazine nucleus was achieved. Moreover, compound1 was subjected to react either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole2 and3, or thiadiazine7 . However, the tetracyclic ring system9 was furnished throughcondensation reaction of isatine with triazine1 . In addition, some of the new synthesized compounds were evaluated as an antioxidant andantitumor agents . Abstract :