Surgical adhesive: Synthesis and properties of thermoresponsive Pluronic L‐31–3, 4–dihydroxyphenylalanine–arginine derivatives. Issue 16 (20th April 2017)

• Record Type: Journal Article
• Authors: Lu, Dedai; Li, Yunfei; Li, Tinģe; Zhang, Yongyong; Dou, Fajuan; Wang, Xiaoying; Zhao, Xiaolong; Ma, Hengchang; Guan, Xiaolin; Wei, Qiangbing; Lei, Ziqiang
• Is Part Of: Journal of applied polymer science. Volume 134:Issue 16(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04-20
• Subjects: bioadhesives -- biocompatibility -- derivatives -- thermo-sensitive -- tissue adhesives; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.44729
• Languages: English
• ISSNs: 0021-8995

Abstract

ABSTRACT: A novel thermosensitive adhesive was synthesized by the esterification reaction of multihydroxyl Pluronic L‐31 with 3, 4‐dihydroxy‐l ‐phenylalanine andl ‐arginine. Pluronic L‐31–DOPA–arginine derivative (PDA) gels, rapidly formed in situ with horseradish peroxidase and hydrogen peroxide, were used to explore the performance of efficient tissue adhesives. The results of their adhesive strength on porcine skin demonstrate that the structure of the polymers and temperature influenced the adhesiveness to tissue of the polymers. Compared with the PDAs at 25 °C, the PDAs at 37 °C showed superior adhesive strength. The attractive performance of the PDA gels were demonstrated by this study's results, which suggest biomedical applications in tissue‐adhesive devices in the future. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2017, 134, 44729. Abstract :