Metal complexes of tridentate tripod ligands in medical imaging and therapy. (29th March 2017)

• Record Type: Journal Article
• Authors: Silva, Francisco; Fernandes, Célia; Campello, Maria Paula Cabral; Paulo, António
• Is Part Of: Polyhedron. Volume 125(2017)
• Page Start: 186
• Page End: 205
• Publication Date: 2017-03-29
• Subjects: 2-TicNMe tris(N-methylimidazol-2-yl)carbonil -- 2-TipiPr2 tris(1, 4-diisopropylimidazol-2-yl)phosphane -- 4-TipH tris(imidazole-4-yl)phosphane -- AO acridine orange -- BBB blood brain barrier -- BBN bombesin -- bdmpza 3, 3-bis(3, 5-dimethylpyrazol-1-yl)acetate -- bdmpzp 3, 3-bis(3, 5-dimethylpyrazol-1-yl)propionate -- BFC bifucntional chelator -- BP bisphophonate -- bpea bis(pyrazolyl)ethylamine -- bpza 3, 3-bis(pyrazol-1-yl)acetate -- bpzp 3, 3-bis(pyrazol-1-yl)propionate -- CAD coronary artery disease -- CORM CO releasing molecule -- CT computed tomography -- CT-DNA circulating tumor DNA -- CuAAC copper-catalyzed azide-alkyne 1, 3-dipolar cycloaddition, "click" addition -- cybpamd N, N-dicyclohexyl-2, 2-bis-(3, 5-dimethylpyrazol-1-yl)-cetamidinate) -- p-cym 1-isopropyl-4-methyl-benzene -- DAP 2, 3-diamino-propionic acid -- DAPTA 3, 7-diacetyl-1, 3, 7-triazaphosphabicyclo[3.3.1]nonane -- DLC delocalized cations -- DMEOP 3, 5-bis(methoxymethyl)pyrazole -- DNA deoxyribonucleic acid -- DOTA 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid -- DPA dipicolylamine -- dpq dipyrido[3, 2-d:2′, 3′-f]quinoxaline -- DTPA diethylenetriaminepentaacetic acid -- GPC G protein coupled -- HEDP (1-hydroxyethylidene)-diphosphonic acid -- HER2 human epidermal growth factor2 -- HOMO Highest Occupied Molecular Orbital -- IC50 half maximal inhibitory concentration -- imzh imidazole -- iNOS nitric oxide synthase inhibitor -- KP1019 trans-[tetrachlorobis(1-H-indazole)ruthenate(III)] -- MDR multidrug resistance -- MRI magnetic resonance imaging -- NAMI-A imidazolium-trans-tetrachloro(dimethylsulfoxide)imidazoleruthenium(III) -- NIR near-infrared -- NOS nitric oxide synthase -- NOTA 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid -- OTf trifluoromethanesulfonate -- PCN tris(2-cyanoethyl)phosphine -- PCy3 tricyclohexylphosphine -- PDT photodynamic therapy -- PET positron emission tomography -- Ph phenyl -- phen 1, 10-phenanthroline -- PSMA prostate specific membrane antigen -- PTA 1, 3, 5-triaza-7-phosphaadamantane -- Py pyridine -- Pz pyrazole -- pz4lut α, α, α, α-tetra(pyrazol-1-yl)-2, 6-lutidine -- RGD arginylglycylaspartic acid -- SLND Sentinel Lymph Node Dissection -- SPECT single photon emission computed tomography -- SPPS solid phase peptide synthesis -- thp tris(hydroxymethyl)phosphine -- TimMe N-methyl-2-mercaptoimidazolyl -- TMEOP 3, 4, 5-tris(methoxymethyl)pyrazole -- Tp tris(pyrazol-1-yl)borate -- Tpa tris(2-pyridyl)amine -- Tpm tris(pyrazol-1-yl)methane -- TpmOH 2, 2, 2-tris(pyrazol-1-yl)ethanol -- TpmOMs 2, 2, 2-tris(pyrazol-1-yl)mesyloxymethyl -- TpmPy 4-{[tris-2, 2, 2-(pyrazol-1-yl)ethoxy]methyl}pyridine -- Tpms tris(pyrazolyl-1-yl)methanesulfonate -- Tpp tris(pyridine-2-yl)phosphane -- TPP triphenylphosphonium -- TpPh tris(3-phenylpyrazolyl)borate -- TNBC triple negative breast cancer -- UNICAM-1 [Ru(p-cym)(bis(3, 5-dimethylpyrazol-1-yl)methane)Cl]Cl; Scorpionates -- Cytotoxic agents -- Photosensitizers -- CORMs -- Radiopharmaceuticals; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2016.11.040
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: This review highlights the most relevant chemical aspects and biological results of scorpionate-containing metal complexes with relevance for biomedical applications, namely as cytotoxic drugs, photosensitizers, CO release molecules (CORMs) or radiopharmaceuticals. Abstract: Since their development in the late 1960s, scorpionate ligands have played a great part in the design of novel compounds in the field of coordination chemistry. In this review we focus on the most relevant scorpionate-containing metal complexes that have been explored in the area of medical imaging and therapy. We intend to provide some insight into the chemistry involved in the design of these compounds, and also highlight relevant biological results that have been reported in the literature for scorpionate complexes as cytotoxic drugs, photosensitizers, CO releasing molecules (CORMs) or radiopharmaceuticals.