Host–guest recognition on photo-responsive cell surfaces directs cell–cell contacts. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Shi, Peng; Ju, Enguo; Wang, Jiasi; Yan, Zhengqing; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Materials today. Volume 20:Issue 1(2017:Jan.)
• Page Start: 16
• Page End: 21
• Publication Date: 2017-01
• Subjects: Materials science -- Periodicals; Metallurgy -- Periodicals; Metal-work -- Periodicals; Biomedical and Dental Materials -- Periodicals; Manufactured Materials -- Periodicals; Metals -- Periodicals; 620.11
• DOI: 10.1016/j.mattod.2016.12.006
• Languages: English
• ISSNs: 1369-7021

Abstract

Abstract : We developed an efficient cell surface engineering method based on lipid-insertion and host–guest recognition. With this methodology, we tailored cell membranes with β-cyclodextrin and subsequently manipulated cell behaviors through introducing photo-switchable guest molecule. Non-covalent nature afforded this method inherent reversibility. Furthermore, considering the remarkable molecular recognition property of aptamer, azobenzene-labeled aptamer was modified on cell surface through host–guest interaction and served as targeting ligand for selectively identifying target cells. Based on these, we designed a cell-based therapy for directing peripheral blood mononuclear cells to induce target cancer cell apoptosis. Our results provide new insights into engineering well-defined molecular recognition event on cell membrane to meet the demands of specific applications.