Risk assessment in paediatric glioma—Time to move on from the binary classification. (March 2017)

• Record Type: Journal Article
• Authors: Dodgshun, A.J.; Hansford, J.R.; Sullivan, M.J.
• Is Part Of: Critical reviews in oncology/hematology. Volume 111(2017)
• Page Start: 52
• Page End: 59
• Publication Date: 2017-03
• Subjects: Glioma -- Risk factors -- Prognosis -- Child; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2017.01.012
• Languages: English
• ISSNs: 1040-8428

Abstract

Highlights: Paediatric glioma encompasses a broad spectrum of disease with highly variable prognoses. Consistent risk factors affecting prognosis are well established for high-grade and low-grade glioma. Risk classification for paediatric glioma is possible and should be pursued. Abstract: Background: Paediatric glioma encompasses a wide range of entities with highly variable prognoses. Gliomas are grouped by histopathological features into high- and low-grade glioma but this classification until recently has not taken into account many emerging risk factors in this disease. A comprehensive risk classification has not been published for paediatric glioma despite many risk factors being established in this disease. Methods: A comprehensive literature review was carried out identifying risk factors for paediatric low-grade and high-grade glioma. Results: The most consistently described risk factors in high-grade glioma included midline location and extent of surgical resection. For patients with progressive unresectable low-grade glioma, age under 1, neurofibromatosis type I status and location were the most consistently prognostic. Molecular classification shows promise in accurately reassigning diagnosis for some gliomas. Conclusion: Risk profiling in paediatric glioma will require a focused multinational effort but will result in a more accurate and nuanced assessment of prognosis.