Sesame allergy threshold dose distribution. (September 2015)

• Record Type: Journal Article
• Authors: Dano, D.; Remington, B.C.; Astier, C.; Baumert, J.L.; Kruizinga, A.G.; Bihain, B.E.; Taylor, S.L.; Kanny, G.
• Is Part Of: Food and chemical toxicology. Volume 83(2015)
• Page Start: 48
• Page End: 53
• Publication Date: 2015-09
• Subjects: Allergy -- Dose distribution -- Modelling -- Sesame -- Threshold; DBPCFC Double Blind Placebo Controlled Food Challenge test -- ED Eliciting Dose -- EU European Union -- LOAEL Lowest Observed Adverse Effect Level -- NOAEL No Observed Adverse Effect Level; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2015.05.011
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Background: Sesame is a relevant food allergen in France. Compared to other allergens there is a lack of food challenge data and more data could help sesame allergy risk management. The aim of this study is to collect more sesame challenge data and investigate the most efficient food challenge method for future studies. Method: Records of patients at University Hospital in Nancy (France) with objective symptoms to sesame challenges were collected and combined with previously published data. An estimation of the sesame allergy population threshold was calculated based on individual NOAELs and LOAELs. Clinical dosing schemes at Nancy were investigated to see if the optimal protocol for sesame is currently used. Results: Fourteen patients (10 M/4 F, 22 ± 14.85 years old) with objective symptoms were added to previously published data making a total of 35 sesame allergic patients. The most sensitive patient reacted to the first dose at challenge of 1.02 mg sesame protein. The ED05 ranges between 1.2 and 4.0 mg of sesame protein (Log-Normal, Log-Logistic, and Weibull models) and the ED10 between 4.2 and 6.2 mg. The optimal food challenge dosing scheme for sesame follows semi-log dose increases from 0.3 to 3000 mg protein. Conclusion: This article provides a valuable update to the existing clinical literature regarding sesame NOAELs and LOAELs. Establishment of a population threshold for sesame could help in increasing the credibility of precautionary labelling and decrease the costs associated with unexpected allergic reactions. Also, the use of an optimal dosing scheme would decrease time spent on diagnostic and thereafter on the economic burden of sesame allergy diagnosis. Highlights: Sesame population threshold dose distribution is defined. Sesame's optimal dosing scheme is proposed. Sesame's optimal dosing scheme could help identify patients with high thresholds. Sesame's optimal dosing scheme could decrease the cost of sesame allergy diagnosis.