Phenolic compounds isolated from Dioscorea zingiberensis protect against pancreatic acinar cells necrosis induced by sodium taurocholate. Issue 6 (15th March 2017)

• Record Type: Journal Article
• Authors: Du, Dan; Jin, Tao; Zhang, Rui; Hu, Liqiang; Xing, Zhihua; Shi, Na; Shen, Yan; Gong, Meng
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 6(2017)
• Page Start: 1467
• Page End: 1470
• Publication Date: 2017-03-15
• Subjects: H2-DCFDA 2, 7-dichloro-dihydrofluorescein diacetate -- NaT sodium taurocholate -- PI propidium iodide; Phenol -- Bibenzyl -- Diarylheptanoid -- Pancreatitis -- Necrosis -- Acinar cell; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.01.014
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: One new bibenzyl (1 ) and one new phenanthrene (2 ), together with two known bibenzyls (3 –4 ) and four known diarylheptanoids (5 –8 ) were isolated from the rhizomes of Dioscorea zingiberensis . The structures of1 –2 were elucidated by spectroscopic methods including 1D and 2D NMR. Phenols1 –8 were evaluated for their anti-pancreatitic activities on sodium taurocholate (NaT)-induced pancreatic acinars necrosis. Notably, 0.5 mM of compound6 exhibited comparable inhibitory effect with 5 mM of caffeine. Furthermore, compound6 prevented the ATP depletion and excessive ROS production which could be also involved in mitochondria-mediated injuries in acute pancreatitis. As a result, compound6 has been demonstrated to be a potential candidate for mediating mitochondrial dysfunction to prevent pancreatic necrosis. This study is also the first report on the isolation of bibenzyls and diarylheptanoids from this plant.