How close are we to complete annotation of metabolomes?. (February 2017)

• Record Type: Journal Article
• Authors: Viant, Mark R; Kurland, Irwin J; Jones, Martin R; Dunn, Warwick B
• Is Part Of: Current opinion in chemical biology. Volume 36(2017)
• Page Start: 64
• Page End: 69
• Publication Date: 2017-02
• Subjects: Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2017.01.001
• Languages: English
• ISSNs: 1367-5931

Abstract

Highlights: No exhaustive experimental characterisation of an organism's metabolome reported. Deep metabolome annotation strategies based on multi-platform assays. International task group formed to help coordinate metabolome annotation. Entering new era of annotation focused on model organisms. Abstract : The metabolome describes the full complement of the tens to hundreds of thousands of low molecular weight metabolites present within a biological system. Identification of the metabolome is critical for discovering the maximum amount of biochemical knowledge from metabolomics datasets. Yet no exhaustive experimental characterisation of any organismal metabolome has been reported to date, dramatically contrasting with the genome sequencing of thousands of plants, animals and microbes. Here, we review the status of metabolome annotation and describe advances in the analytical methodologies being applied. In part through new international coordination, we conclude that we are now entering a new era of metabolome annotation.