Nuclear Calcium in Cardiac Myocytes. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Ljubojevic, Senka; Bers, Donald M.
• Is Part Of: Journal of cardiovascular pharmacology. Volume 65:Issue 3(2015)
• Publication Date: 2015-03
• Subjects: nuclear calcium -- cardiomyocyte -- calcium signaling -- cardiac remodeling; Cardiovascular Diseases -- drug therapy -- Periodicals; Cardiovascular System -- drug effects -- Periodicals; Cardiovascular pharmacology -- Periodicals; Cardiovascular agents -- Periodicals; Cardiovascular agents; Cardiovascular pharmacology; Periodicals; 615.7105
• DOI: 10.1097/FJC.0000000000000174
• Languages: English
• ISSNs: 0160-2446

Abstract

Abstract : Abstract: Calcium (Ca 2+ ) is a universal second messenger involved in the regulation of various cellular processes, including electrical signaling, contraction, secretion, memory, gene transcription, and cell death. In heart, Ca 2+ governs cardiomyocyte contraction, is central in electrophysiological properties, and controls major signaling pathway implicated in gene transcription. How cardiomyocytes decode Ca 2+ signal to regulate gene expression without interfering with, or being controlled by, "contractile" Ca 2+ that floods the entire cytosol during each heartbeat is still elusive. In this review, we summarize recent findings on nuclear Ca 2+ regulation and its downstream signaling in cardiomyocytes. We will address difficulties in reliable quantification of nuclear Ca 2+ fluxes and discuss its role in the development and progression of cardiac hypertrophy and heart failure. We also point out key open questions to stimulate future work.