Impact of Seasonality on the Prevalence of Dyslipidemia: A Large Population Study. (October 2013)

• Record Type: Journal Article
• Authors: Moura, Filipe A.; Dutra-Rodrigues, Marcelo S.; Cassol, Angela S.; Parra, Eliane S.; Zago, Vanessa H. S.; Panzoldo, Natalia B.; Alexandre, Fernanda; Vieira, Isabela C.; Vendrame, Felipe; Virginio, Vitor W.; Castanho, Vera S.; Danelon, Mirian R. G.; Nunes, Valeria S.; Leança, Camila C.; Saraiva, Francisco K.; Coelho, Otavio R.; Nakandakare, Edna; Quintão, Eder C. R.; de Faria, Eliana Cotta; Sposito, Andrei C.
• Is Part Of: Chronobiology international. Volume 30:Number 8(2013)
• Page Start: 1011
• Page End: 1015
• Publication Date: 2013-10
• Subjects: Lipid profile -- primary prevention -- seasonality; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.3109/07420528.2013.793698
• Languages: English
• ISSNs: 0742-0528

Abstract

Abstract : Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these parameters, which may cause under- or overestimation. Biological rhythms and seasonal variation of lipid profile was investigated in 227 359 consecutive individuals who underwent health checkups in primary care centers between 2008 and 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL was 8% more prevalent during winter than summer, with a larger difference among women and middle-aged adults ( p < 0.001). High-density lipoprotein cholesterol (HDL-C) <40 mg/dL and triglycerides (TG) >150 mg/dL were respectively 9% and 5% more prevalent during the summer ( p < 0.001). Variation amplitude was 3.4 ± 0.3 mg/dL for HDL-C ( p = 0.005), 7 ± 2 mg/dL for LDL-C ( p = 0.047), and 12 ± 9 mg/dL for TG ( p = 0.058). Based on a large population sample, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of relative risk, prevalence, or the rate of goal achievement for lipid parameters.