Asymmetric addition of 3-substituted benzofuran-2-ones to isatin N-Boc ketimines catalyzed by chiral biscinchona alkaloid catalyst. Issue 24 (17th June 2015)
- Record Type:
- Journal Article
- Title:
- Asymmetric addition of 3-substituted benzofuran-2-ones to isatin N-Boc ketimines catalyzed by chiral biscinchona alkaloid catalyst. Issue 24 (17th June 2015)
- Main Title:
- Asymmetric addition of 3-substituted benzofuran-2-ones to isatin N-Boc ketimines catalyzed by chiral biscinchona alkaloid catalyst
- Authors:
- Zhu, Yi
Zhang, Enge
Luo, Chao
Li, Xin
Cheng, Jin-Pei - Abstract:
- Abstract: A highly enantioselective Mannich reaction of 3-substituted benzofuran-2(3 H )-ones and isatin N -Boc ketimines catalyzed by a chiral biscinchona alkaloid catalyst was developed, which proved to be an efficient way for the synthesis of chiral 3, 3′-disubstituted benzofuran-2-one derivatives. The nucleophilic addition products were generally obtained in high yields (up to 99%) with very good diastereoselectivities (up to >95:5 dr) and enantioselectivities (up to 98% ee). Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 24(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 24(2015)
- Issue Display:
- Volume 71, Issue 24 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 24
- Issue Sort Value:
- 2015-0071-0024-0000
- Page Start:
- 4090
- Page End:
- 4097
- Publication Date:
- 2015-06-17
- Subjects:
- Organocatalysis -- Mannich reaction -- Benzofuranone -- Oxindole -- N-Boc ketimine
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2015.04.114 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1189.xml