Ligand‐free CuI‐catalyzed coupling and cyclization of β‐bromo‐α, β‐unsaturated amides with formamide leading to pyrimidinones. (23rd July 2013)

• Record Type: Journal Article
• Authors: Ho, Son Long; Cho, Chan Sik
• Is Part Of: Applied organometallic chemistry. Volume 27:Number 9(2013:Sep.)
• Page Start: 507
• Page End: 511
• Publication Date: 2013-07-23
• Subjects: β‐bromo‐α, β‐unsaturated amides -- coupling and cyclization -- copper catalyst -- formamide -- pyrimidinones; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3016
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : β‐Bromo‐α, β‐unsaturated amides were coupled and cyclized with formamide in DMF at 100°C in the presence of a catalytic amount of a copper(I) salt along with a base to give the corresponding pyrimidinones in good yields. Copyright © 2013 John Wiley & Sons, Ltd. Abstract : β‐Bromo‐α, β‐unsaturated amides react with formamide in the presence of CuI along with Cs2 CO3 to give pyrimidinones.