Assessing human brain impedance using simultaneous surface and intracerebral recordings. (20th February 2017)

• Record Type: Journal Article
• Authors: Ranta, Radu; Le Cam, Steven; Tyvaert, Louise; Louis-Dorr, Valérie
• Is Part Of: Neuroscience. Volume 343(2017)
• Page Start: 411
• Page End: 422
• Publication Date: 2017-02-20
• Subjects: CSD current source density -- LFP local field potentials -- SEEG stereoelectoencephalogram -- ECoG electrocorticogram -- EEG electroencephalogram -- PSD power spectral density; brain impedance -- simultaneous EEG–SEEG -- intracerebral stimulation -- computational current source models; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.12.013
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Original experimental method for assessing the head tissues' frequency responses. Similar frequency responses (gain excluded), independent of source–sensor distances. Fractional computational models with few parameters for the synaptic current sources. Favorable comparison with kinetic/computational models for different synapses. Simulated LFP signals having the frequency characteristics reported in the literature. Abstract: Most of the literature on the brain impedance proposes a frequency-independent resistive model. Recently, this conclusion was tackled by a series of papers (Bédard et al., 2006; Bédard and Destexhe, 2009; Gomes et al., 2016), based on microscopic sale modeling and measurements. Our paper aims to investigate the impedance issue using simultaneous in vivo depth and surface signals recorded during intracerebral electrical stimulation of epileptic patients, involving a priori different tissues with different impedances. Our results confirm the conclusions from Logothethis et al. (2007): there is no evidence of frequency dependence of the brain tissue impedance (more precisely, there is no difference, in terms of frequency filtering, between the brain and the skull bone), at least at a macroscopic scale. In order to conciliate findings from both microscopic and macroscopic scales, we recall different neural/synaptic current generators' models from the literature and we propose an original computational model, based on fractional dynamics.