Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: van der Esch, M.; Knoop, J.; van der Leeden, M.; Roorda, L.D.; Lems, W.F.; Knol, D.L.; Dekker, J.
• Is Part Of: Osteoarthritis and cartilage. Volume 23:Issue 4(2015)
• Page Start: 544
• Page End: 549
• Publication Date: 2015-04
• Subjects: Osteoarthritis -- Knee [Mesh] -- Muscle strength [Mesh] -- Phenotype [Mesh] -- Obesity [Mesh] -- Depressive disorder [Mesh]; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2015.01.006
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics. Methods: Knee OA patients ( N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA. Results: Cluster analysis identified five phenotypes of knee OA patients: "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype". Conclusions: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.