The analysis of clinico-pathologic characteristics in patients who underwent surgery due to stricturing and non-perineal fistulizing forms of Crohn's disease: A retrospective cohort study. (March 2015) - Cayci, Murat
Abstract: Background: The diagnosis of Crohn's disease is based mainly on the patient's history and clinical examination and supported by serologic, radiologic, endoscopic, and histologic findings. Aims: The main purpose of the present study was to evaluate in a retrospective manner the clinico-pathological characteristics of patients who underwent surgery due to stricturing or non perineal fistulizing Crohn's disease. Material and methods: Between January 2007 and June 2012, 75 patients who were operated on for stricturing and non-perineal fistulizing forms of Crohn's disease were analyzed according to their clinico-pathological characteristics. Results: The L3 localization (Montreal Classification) was detected significantly more often in the non-perineal fistulizing group than in the stricturing group ( P < 0.03). Wound infection (18 patient, 24%) was the most commonly observed postoperative complication, followed by postoperative ileus (5 patients, 6.7%) and intraabdominal abscess (4 patients, 5.2%). The distribution of postoperative complications according to the two groups was not significantly different ( P = 0.772). Submucosal fibrosis, ulcers and transmural inflammation were the three most common histopathological signs in resected specimens from both groups. Pseudopolyps, microabscess, granuloma, mononuclear inflammation and deep fissures were significantly far more frequent in the non perineal fistulizing group when compared to the stricturing group ( P < 0.05). On the other hand, superficial ulcers were significantly more frequent in the stricturing group ( P = 0.007). Conclusion: No specific clinical feature was found to differentiate patients with the stricturing form of Crohn's disease from the fistulizing form. However, histopathological analysis of the resected specimens revealed significant differences in some parameters between the two disease forms. Highlights: There is still no common etiopathogenetic model for all forms of Crohn's disease. Data is limited regarding clinico-pathologic characteristics of the stricturing and non perineal fistulizing forms. No specific clinical feature was found in the present study between the two disease forms. Histopathological analysis revealed significant differences in some parameters.