Diamine acylation with amino acid derivatives: an example of proximity effect in organic reactivity induced by supramolecular aggregation. Issue 9 (25th February 2015) - Felip-León, Carles
Graphical abstract: Abstract: Unexpected high yields of diamide3 are obtained in the reaction of 1, 3-propanediamine with an activated ester ofl -valine (1 ) under adverse proportions of the reactants, namely in the presence of an excess of 1, 3-propanediamine. It is observed using different conditions that the yield of difunctionalized compound is considerably higher than that expected from a statistical distribution of products. Proximity effects associated to supramolecular interactions explain the described reactivity.