Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Issue 2 (7th February 2017)

• Record Type: Journal Article
• Authors: Karam, O.; Demaret, P.; Duhamel, A.; Shefler, A.; Spinella, P. C.; Tucci, M.; Leteurtre, S.; Stanworth, S. J.
• Other Names: Butt Warwick investigator.; Elope Carmel investigator.; Bain Kym investigator.; Erickson Simon investigator.; Smalley Nathan investigator.; Dorofaeff Tavey investigator.; Long Debbie investigator.; Smalley Nathan investigator.; Wiseman Greg investigator.; de Cléty Stéphan Clément investigator.; Berghe Caroline investigator.; de Jaeger Annick investigator.; Trippaerts Marc investigator.; Willems Ariane investigator.; Rooze Shancy investigator.; De Dooy Jozef investigator.; Gilfoyle Elaine investigator.; Wohlgemuth Lynette investigator.; Dumitrascu Mariana investigator.; Withington Davinia investigator.; Hickey Julia investigator.; Choong Karen investigator.; Sanders Lois investigator.; Morrison Gavin investigator.; Tijssen Janice investigator.; Wensley David investigator.; Krahn Gordon investigator.; Dugas Marc‐Andre investigator.; Gosselin Louise investigator.; Santschi Miriam investigator.; Von Dessauer Bettina investigator.; Ordenes Nadia investigator.; Afshari Arash investigator.; Andersen Lasse Hoegh investigator.; Nilsson Jens Christian investigator.; Johansen Mathias investigator.; Jensen Anne‐Mette Baek investigator.; Mino Santiago Campos investigator.; Grunauer Michelle investigator.; Joram Nicolas investigator.; Roullet‐Renoleau Nicolas investigator.; Javouhey Etienne investigator.; Cour‐Andlauer Fleur investigator.; Portefaix Aurélie investigator.; Brissaud Olivier investigator.; Guichoux Julie investigator.; Payen Valérie investigator.; Léger Pierre‐Louis investigator.; Afanetti Mickael investigator.; Mortamet Guillaume investigator.; Maria Matthieu investigator.; Breining Audrey investigator.; Tissieres Pierre investigator.; Dorkenoo Aimée investigator.; Deho Anna investigator.; Steinherr Harry investigator.; Nikolaou Filippia investigator.; Camporesi Anna investigator.; Mario Federica investigator.; Kawasaki Tatsuya investigator.; Miura Shinya investigator.; Beca John investigator.; Rea Miriam investigator.; Sherring Claire investigator.; Bushell Tracey investigator.; Bentsen Gunnar investigator.; Dinis Alexandra investigator.; Pereira Gabriela investigator.; Vieira Marisa investigator.; Moniz Marta investigator.; Alshehri Saleh investigator.; Alasnag Manal investigator.; Rajab Ahmad investigator.; Pisarcikova Maria investigator.; Jordan Iolanda investigator.; Balcells Joan investigator.; Perez‐Ferrer Antonio investigator.; de Vicente Sánchez Jesús investigator.; Moyano Marta Vazquez investigator.; Martinez Antonio Morales investigator.; Lopez‐Herce Jesus investigator.; Solana Maria Jose investigator.; González Jose Carlos Flores investigator.; Alonso Maria Teresa investigator.; Faza Manuel Nieto investigator.; Perez Marie‐Hélène investigator.; Amiet Vivianne investigator.; Doell Carsten investigator.; Bordessoule Alice investigator.; Otter Suzan Cochius‐den investigator.; Kapitein Berber investigator.; Kneyber Martin investigator.; Brierley Joe investigator.; Rea Vanessa investigator.; McKeever Stephen investigator.; Kelleher Andrea investigator.; Scholefield Barney investigator.; Top Anke investigator.; Kelly Nicola investigator.; Virdee Satnam investigator.; Davis Peter investigator.; George Susan investigator.; Hawkins Kay C investigator.; McCall Katie investigator.; Brown Victoria investigator.; Sykes Kim investigator.; Levin Richard investigator.; MacLeod Isobel investigator.; Horan Marie investigator.; Jirasek Petr investigator.; Inwald David investigator.; Abdulla Amina investigator.; Raghunanan Sophie investigator.; Sparkes Hannah investigator.; Hanson Sheila investigator.; Woods Katherine investigator.; Triscari David investigator.; Murkowski Kathy investigator.; Ozment Caroline investigator.; Steiner Marie investigator.; Nerheim Dan investigator.; Galster Amanda investigator.; Higgerson Renee investigator.; Christie LeeAnn investigator.; Martin Daniel investigator.; Rourke Liz investigator.; Muszynski Jennifer investigator.; Steele Lisa investigator.; Ajizian Samuel investigator.; McCrory Michael C investigator.; O'Brien Kevin investigator.; Babbitt Christopher investigator.; Felkel Erin investigator.; Levine Glenn investigator.; Truemper Edward J investigator.; Zink Machelle investigator.; Nellis Marianne investigator.; Thomas Neal J investigator.; Spear Debbie investigator.; Markovitz Barry investigator.; Terry Jeff investigator.; Morzov Rica investigator.; Montgomery Vicki investigator.; Michael Andrew investigator.; Thomas Melissa investigator.; Singleton Marcy investigator.; Jarvis Dean investigator.; Nett Sholeen investigator.; Willson Douglas investigator.; Hoot Michelle investigator.; Bembea Melania investigator.; Yiu Alvin investigator.; McKinley David investigator.; Scarlett Elizabeth investigator.; Sankey Jennifer investigator.; Parikh Minal investigator.; Faustino E. Vincent S. investigator.; Michelson Kelly investigator.; Rilinger Jay investigator.; Campbell Laura investigator.; Gertz Shira investigator.; Cholette Jill M. investigator.; Jeyapalan Asumthia investigator.; Parker Margaret investigator.; Bateman Scot investigator.; Johnson Amanda investigator.;
• Is Part Of: Vox sanguinis. Volume 112:Issue 2(2017)
• Page Start: 140
• Page End: 149
• Publication Date: 2017-02-07
• Subjects: blood component transfusion -- child -- critical illness -- plasma; Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.12490
• Languages: English
• ISSNs: 0042-9007

Abstract

Abstract : Background and Objectives: Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to >5% of their patients, whereas another 25% transfused plasma to <1% of their patients. The objective of this study was to explore the factors associated with different plasma transfusion practices in these centres. Materials and Methods: Online survey sent to the local investigators of the 101 participating centres, in February 2016. Four areas were explored: beliefs regarding plasma transfusion, patients' case‐mix in each unit, unit's characteristics, and local blood product transfusion policies and processes. Results: The response rate was 82% (83/101). 43% of the respondents believed that plasma transfusions can arrest bleeding, whereas 27% believe that plasma transfusion can prevent bleeding. Centres with the highest plasma transfusion rate were more likely to think that hypovolaemia and mildly abnormal coagulation tests are appropriate indications for plasma transfusions ( P = 0·02 and P = 0·04, respectively). Case‐mix, centre characteristics or local transfusion services were not identified as significant relevant factors. Conclusion: Factors influencing plasma transfusion practices reflect beliefs about indications and the efficacy of transfusion in the prevention and management of bleeding as well as effects on coagulation tests. Educational and other initiatives to target these beliefs should be the focus of research.