Genetic polymorphism of miR‐146a is associated with gastric cancer risk: a meta‐analysis. (23rd July 2015)

• Record Type: Journal Article
• Authors: Sun, Y.; Li, M.
• Is Part Of: European journal of cancer care. Volume 26:Number 2(2017:Mar.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-07-23
• Subjects: miR‐146a -- polymorphism -- gastric cancer -- meta‐analysis; Cancer -- Nursing -- Periodicals; 616.994
• DOI: 10.1111/ecc.12355
• Languages: English
• ISSNs: 0961-5423

Abstract

Abstract : Several studies have investigated the associations between miR‐146a rs2910164 and gastric cancer (GC) risk, but results have been inconclusive. To derive a more precise estimation of the relationship, a meta‐analysis was performed. PubMed and China National Knowledge Infrastructure searches were carried out for relevant studies published before July 2014. Meta‐analysis was performed with thestata, version 11.0. A total of seven case–control studies, including 3283 cases and 4535 controls, were selected. A significant association was found between rs2910164 and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66–0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71–0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73–0.91) for the total data. In the subgroup analysis by ethnicity, statistically significant association was found in Asian. This meta‐analysis suggested that the miR‐146a rs2910164 was a risk factor for developing GC.