HIV‐1 neutralizing antibodies: understanding nature's pathways. Issue 1 (16th June 2013)

• Record Type: Journal Article
• Authors: Mascola, John R.; Haynes, Barton F.
• Is Part Of: Immunological reviews. Volume 254:Issue 1(2013:Jul.)
• Page Start: 225
• Page End: 244
• Publication Date: 2013-06-16
• Subjects: monoclonal antibodies (mAbs) -- broadly neutralizing antibodies (BNAbs) -- unmutated ancestor (UA) -- B‐cell lineages -- immune tolerance; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12075
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: The development of an effective vaccine has been hindered by the enormous diversity of human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune responses. In addition, conserved vulnerable regions on the HIV‐1 envelope glycoprotein are often poorly immunogenic and elicit broadly neutralizing antibody responses (BNAbs) in a minority of HIV‐1‐infected individuals and only after several years of infection. All of the known BNAbs demonstrate high levels of somatic mutations and often display other unusual traits, such as a long heavy chain complementarity determining region 3 (CDRH3) and autoreactivity that can be limited by host tolerance controls. Nonetheless, the demonstration that HIV‐1‐infected individuals can make potent BNAbs is encouraging, and recent progress in isolating such antibodies and mapping their immune pathways of development is providing new strategies for vaccination.