Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells. (3rd April 2017)

• Record Type: Journal Article
• Authors: Vural, Altugan Cahit; Odabas, Sedat; Korkusuz, Petek; Yar Sağlam, Atiye Seda; Bilgiç, Elif; Çavuşoğlu, Tarık; Piskin, Erhan; Vargel, İbrahim
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 3(2017)
• Page Start: 544
• Page End: 550
• Publication Date: 2017-04-03
• Subjects: Bone morphogenetic protein-2 -- cranial bone regeneration -- critical size defect -- mesenchymal stem cell -- transfection; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2016.1160918
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6 mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.