4-hydroxybenzaldehyde-chitooligomers suppresses H2O2-induced oxidative damage in microglia BV-2 cells. (22nd February 2017)

• Record Type: Journal Article
• Authors: Oh, Sea-Hun; Ryu, BoMi; Ngo, Dai-Hung; Kim, Won-Suk; Kim, Dong Gyu; Kim, Se-Kwon
• Is Part Of: Carbohydrate research. Volume 442(2017)
• Page Start: 32
• Page End: 37
• Publication Date: 2017-02-22
• Subjects: 4-hydroxybenzaldehyde-COS (HB-COS) -- Oxidative stress -- Microglia BV-2 cells; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2017.01.007
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Positive charges of chitooligomer (COS) enable COS to interact with negatively charged anionic groups on the cell surface resulting in an improvement in the biological activity of COS and its derivatives. In this study, 4-hydroxybenzaldehyde-COS (HB-COS) was synthesized and investigated for its abilities against H2 O2 -induced oxidative stress in microglia BV-2 cells. Under oxidative stress, HB-COS significantly attenuated reactive oxygen species (ROS) generation and DNA oxidation, and upregulated the protein levels of antioxidative enzymes. HB-COS is therefore proposed as a potential protective agent against neuronal damage. Graphical abstract: Highlights: 4-hydroxybenzaldehyde-COS (HB-COS) was synthesized and characterized. Abilities of HB-COS in H2 O2 -induced oxidative stress was compared with ascorbic acid. HB-COS has potency as a protective agent against neuronal damage.