The First Hand Allotransplantation in Taiwan: A Report at 9 Months. (February 2016)

• Record Type: Journal Article
• Authors: Kuo, Yur-Ren; Chen, Chien-Chang; Chen, Yen-Chou; Yeh, Ming-Chung; Lin, Pao-Yuan; Lee, Chen-Hsiang; Chang, Jui-Kun; Lin, Yi-Chun; Huang, Shun-Chen; Chiang, Yuan-Cheng; Chiu, Nien-Mu; Lee, Yu; Huang, Yu-Chi; Liang, Jiun-Lung; Wu, Re-Wen; Siu, Ka-Kit; Chung, Kuan-Chih; Chiang, Min-Hsien; Pan, Cheng-Chung; Wei, Fu-Chan
• Is Part Of: Annals of plastic surgery. Volume 77(2016:Jul.)Supplement 1
• Publication Date: 2016-02
• Subjects: hand allotransplantation -- immunosuppressive drug; Surgery, Plastic -- Periodicals; 617.95205
• DOI: 10.1097/SAP.0000000000000758
• Languages: English
• ISSNs: 0148-7043

Abstract

Abstract : Purpose: Hand transplantations have been initiated and have been encouraged by promising results for more than 1 decade. The aim of this study was to present the first case of hand transplantation performed in Taiwan. Materials and Methods: On September 3, 2014, we transplanted the left distal forearm and hand of a brain-dead managed 37 years to a man aged 45 years who had traumatic amputation of the distal third of his right forearm 30 years ago. The total ischemic time during the transplantation was 6 hours and 45 minutes. Immunosuppression included anti-thymocyte globulins, and methylprednisolone (Solumedrol) was used for the induction. Maintenance therapy included systemic tacrolimus, mycophenolic acid [mycophenolate mofetil (MMF)], and prednisone. A combination of systemic (tacrolimus/MMF/prednisolone) and topical immunosuppressant cream (clobetasol and tacrolimus) was applied if acute rejection occurred. Follow-up included routine posttransplant laboratory tests, skin biopsies, intensive physiotherapy, and psychological support. Results: The initial postoperative course was uneventful. No surgical complications were observed. Immunosuppression was well tolerated using tacrolimus, MMF, and prednisone, except for some immune-related complications. One episode of mild clinical and histological signs of cutaneous rejection was seen at 105 days after surgery. These signs disappeared after pulse therapy with Solumedrol and the topical application of immunosuppressive creams (tacrolimus and clobetasol). One infection episode occurred due to local cellulitis and axillary lymphadenopathy on day 140 and was successfully treated with antibiotics. The patient developed cytomegalovirus infection at 7 months that responded to medication. Intensive physiotherapy led to satisfactory progress in motor functioning. Sensory progress (Tinel sign) was good and reached the wrist by 3 months for the median and ulnar nerves, and could be felt in the finger tip by 9 months in response to deep pressure and light touch sensations. The patient has a lateral pinch that allows him to pick up and grip objects during daily living, although his muscle power is still insufficient. Conclusions: Hand allotransplantation is technically feasible. Currently available immunosuppression methods seem to control vascularized composite tissue allotransplantation rejection. A combination of topical and systemic immunosuppressants is a useful method to prevent acute hand allotransplant rejection. Abstract : Supplemental digital content is available in the text.