Ribosome Biogenesis is Necessary for Skeletal Muscle Hypertrophy. Issue 3 (July 2016)

• Record Type: Journal Article
• Authors: Wen, Yuan; Alimov, Alexander P.; McCarthy, John J.
• Is Part Of: Exercise and sport sciences reviews. Volume 44:Issue 3(2016:Jul.)
• Publication Date: 2016-07
• Subjects: skeletal muscle -- hypertrophy -- ribosome -- translational capacity -- protein synthesis; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000082
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy. Abstract : Ribosome biogenesis is a primary factor underlying the increase in protein synthesis required for skeletal muscle hypertrophy.