Different NT-proBNP circulating levels for different types of cardiac amyloidosis. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Perfetto, Federico; Bergesio, Franco; Grifoni, Elisa; Fabbri, Alessia; Ciuti, Gabriele; Frusconi, Sabrina; Angelotti, Paola; Spini, Valentina; Cappelli, Francesco
• Is Part Of: Journal of cardiovascular medicine. Volume 17:Issue 11(2016:Nov.)
• Publication Date: 2016-11
• Subjects: cardiac biomarkers -- echocardiography -- immunoglobulin light-chain amyloidosis -- left ventricular mass index -- mutated transthyretin amyloidosis -- wild-type transthyretin amyloidosis; Cardiology -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cardiology -- Periodicals; Cardiovascular Diseases -- Periodicals; 616.1005
• DOI: 10.2459/JCM.0000000000000349
• Languages: English
• ISSNs: 1558-2027

Abstract

Abstract : Aim: Several studies suggest that the N-terminal fragment of pro-brain natriuretic peptide levels are quite different in wild-type transthyretin (TTR)-related amyloidosis (ATTRwt) and mutated TTR-related amyloidosis (ATTRm) compared with immunoglobulin light-chain cardiac amyloidosis. Our aim was to test this hypothesis in a cohort of patients with different types of cardiac amyloidosis. Patients and methods: Seventy patients with ATTRwt, ATTRm, and light-chain cardiac amyloidosis matched for left ventricular (LV) mass index were studied by standard echocardiography, tissue Doppler imaging, and plasmatic cardiac biomarkers. Results: Despite similar LV mass and renal function, patients with ATTR cardiac amyloidosis showed lower levels of N-terminal fragment of pro-brain natriuretic peptide than do light-chain amyloidosis ones, especially when expressed as a function of LV mass index. Conclusion: Amyloidogenic light-chain-derived fibrils induce more severe myocardial dysfunction in light-chain amyloidosis than in ATTR, despite similar myocardial infiltration. Thus, the degree of cardiac dysfunction may be related not only to the amount of amyloid deposited, but also to qualitative differences among fibrils.