Recent Trends in Survival of Patients With Pancreatic Cancer in Germany and the United States. Issue 6 (July 2016)

• Record Type: Journal Article
• Authors: Sirri, Eunice; Castro, Felipe Andres; Kieschke, Joachim; Jansen, Lina; Emrich, Katharina; Gondos, Adam; Holleczek, Bernd; Katalinic, Alexander; Urbschat, Iris; Vohmann, Claudia; Brenner, Hermann
• Is Part Of: Pancreas. Volume 45:Issue 6(2016)
• Publication Date: 2016-07
• Subjects: pancreatic ductal adenocarcinoma -- period analysis -- relative survival; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000588
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. Methods: Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn from 12 population-based German cancer registries and the US SEER (Surveillance, Epidemiology and End Results) 13 registries database. Using period analysis, 5-year RS for 2007 to 2010 was derived. Model-based period analysis was used to assess 5-year RS time trends, 2002–2010. Results: In total 28, 977 (Germany) and 34, 793 (United States) patients aged 15 to 74 years were analyzed. Five-year RS was 10.7% and 10.3% in Germany and the United States, respectively, and strongly decreased with age and tumor spread. Prognosis slightly improved from the period 2002–2004 to 2008–2010 (overall age-adjusted RS: +2.5% units in Germany and +3.4% units in the United States); improvement was particularly strong for regional stage and head and body subsites in Germany and for localized and regional stages and tail subsite in the United States. Conclusions: Although pancreatic cancer survival continues to be poor for advanced-stage patients, our study disclosed encouraging indications of first improvements in 5-year RS after decades of stagnation. Abstract : Supplemental digital content is available in the text.