Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Issue 6 (July 2016)

• Record Type: Journal Article
• Authors: Setiawan, Veronica Wendy; Pandol, Stephen J.; Porcel, Jacqueline; Wilkens, Lynne R.; Le Marchand, Loïc; Pike, Malcolm C.; Monroe, Kristine R.
• Is Part Of: Pancreas. Volume 45:Issue 6(2016)
• Publication Date: 2016-07
• Subjects: epidemiology -- pancreatitis -- alcohol -- smoking; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000657
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: We conducted a prospective analysis of 145, 886 participants in the multiethnic cohort to examine the relationship of alcohol drinking and smoking with pancreatitis. Methods: Pancreatitis cases were categorized as gallstone-related acute pancreatitis (GSAP) (N = 1, 065), non-GSAP (N = 1, 222), and recurrent acute (RAP)/chronic pancreatitis (CP) (N = 523). We used the baseline questionnaire to identify alcohol intake and smoking history. Associations were estimated by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models. Results: Cigarette smoking was associated with non-GSAP and RAP/CP. Moderate alcohol intake was inversely associated with all types of pancreatitis in women (HRs, 0.66 to 0.81 for <1 drink per day), and with RAP/CP in men (HR, 0.57; 95% CI, 0.41–0.79 for <2 drinks per day). The risk of non-GS pancreatitis associated with current smoking was highest among men who consumed more than 4 drinks per day (HR, 2.06; 95% CI, 1.28–3.30), whereas among never smokers, moderate drinking was associated with a reduced risk (HR, 0.70; 95% CI, 0.51–0.96). In women, drinking less than 2 drinks per day was associated with a reduced risk of GSAP among never smokers (HR, 0.61; 95% CI, 0.46–0.80). Conclusions: Smoking is a risk factor for non-GS pancreatitis. Moderate alcohol intake is protective against all types of pancreatitis in women and against RAP/CP in men. Abstract : Supplemental digital content is available in the text.