Anti-N-Methyl-D-Aspartate Receptor Antibody Mediated Neurologic Relapse Post Herpes Simplex Encephalitis: A Case Series. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Geoghegan, Sarah; Walsh, Aoibhinn; King, Mary D.; Lynch, Bryan; Webb, David; Twomey, Eilish; Ronan Leahy, T.; Butler, Karina; Gavin, Patrick
• Is Part Of: Pediatric infectious disease journal. Volume 35:Issue 8(2016)
• Publication Date: 2016-08
• Subjects: herpes simplex encephalitis -- N-methyl-D-aspartate receptor -- relapse of herpes simplex encephalitis -- movement disorder post herpes simplex encephalitis; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001205
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Despite the advent of antiviral therapy, herpes simplex encephalitis (HSE) remains a devastating condition with significant morbidity and mortality. Neurologic relapse after initial improvement is generally attributed to herpes simplex virus reactivation. In 2013, inflammation caused by anti- N -methyl-D-aspartate receptor antibodies was reported in association with cases of neurologic relapse after herpes simplex encephalitis. We present 3 such cases and discuss diagnostic and management dilemmas. Abstract : Supplemental Digital Content is available in the text.