The Neurobiology of Anesthetic Emergence. Issue 3 (July 2016)

• Record Type: Journal Article
• Authors: Tarnal, Vijay; Vlisides, Phillip E.; Mashour, George A.
• Is Part Of: Journal of neurosurgical anesthesiology. Volume 28:Issue 3(2016:Jul.)
• Publication Date: 2016-07
• Subjects: general anesthesia -- emergence -- neural inertia -- systems neuroscience -- neuroanesthesia; Anesthesia in neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 617.96748
• DOI: 10.1097/ANA.0000000000000212
• Languages: English
• ISSNs: 0898-4921

Abstract

Abstract : Achieving a smooth and rapid emergence from general anesthesia is of particular importance for neurosurgical patients and is a clinical goal for neuroanesthesiologists. Recent data suggest that the process of emergence is not simply the mirror image of induction, but rather controlled by distinct neural circuits. In this narrative review, we discuss (1) hysteresis, (2) the concept of neural inertia, (3) the asymmetry between the neurobiology of induction and emergence, and (4) recent attempts at actively inducing emergence.