Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies. Issue 10 (October 2016)

• Record Type: Journal Article
• Authors: Febvey, Olivia; Schüz, Joachim; Bailey, Helen D.; Clavel, Jacqueline; Lacour, Brigitte; Orsi, Laurent; Lightfoot, Tracy; Roman, Eve; Vermeulen, Roel; Kromhout, Hans; Olsson, Ann
• Is Part Of: Journal of occupational and environmental medicine. Volume 58:Issue 10(2016)
• Page Start: 1046
• Page End: 1052
• Publication Date: 2016-10
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000000852
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure. Methods: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs). Results: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95). Conclusion: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.