Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia. (October 2016)

• Record Type: Journal Article
• Authors: Curtis, David
• Is Part Of: Psychiatric genetics. Volume 26:Number 5(2016:Oct.)
• Publication Date: 2016-10
• Subjects: association -- histone modification -- pathway analysis -- schizophrenia; Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000132
• Languages: English
• ISSNs: 0955-8829

Abstract

Abstract : Weighted burden pathway analysis was applied to whole exome sequence data for 2045 schizophrenic patients and 2045 controls. Overall, there was a statistically significant excess of pathways with more rare, functional variants in cases than in controls. Among the highest ranked were pathways relating to histone modification, as well as neuron differentiation and membrane and vesicle function. This bolsters the evidence from previous studies that histone modification pathways may be important in the aetiology of schizophrenia.