Increased Background Activity in DMSA Scintigraphy of a Nonazotemic Patient With β-Thalassemia Major. (September 2016)

• Record Type: Journal Article
• Authors: Paschali, Anna; Tsiouris, Spyridon
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 9(2016)
• Publication Date: 2016-09
• Subjects: β-thalassemia major -- background tracer activity -- DMSA scan -- renal tubular disorders; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001270
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Renal DMSA uptake provides an index for evaluation of the functional tubular mass, which depends on the renal blood flow, proximal tubular cell membrane function, and urinary acid-base balance. We present a case of a nonazotemic 48-year-old adult with β-thalassemia major under regular blood transfusions and iron chelation therapy that underwent DMSA scan showing minor cortical abnormalities and high background activity, featuring prominent cardiac blood pool and liver uptake. This case highlights the pitfall of high background activity during DMSA study in patients with β-thalassemia major due to tubular disorders.