Chronic Lymphocytic Leukemia With Hodgkin and Reed-Sternberg (HRS) Cells: A Potential Diagnostic Pitfall in Lymph Node Biopsies. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Agrawal, Parimal; Bal, Amanjit; Das, Ashim; Sachdeva, ManUpdesh; Prakash, Gaurav
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 25:Issue 1(2017)
• Publication Date: 2017-01
• Subjects: chronic lymphocytic leukemia -- Hodgkin and Reed-Sternberg (HRS) cells -- Richter transformation; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000345
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : Chronic lymphocytic leukemia (CLL) is known to undergo Richter transformation in a proportion of cases. Transformation into Hodgkin lymphoma has been described in a minority of the cases. However, CLL rarely also shows Hodgkin and Reed-Sternberg cells with a classic morphology and the immunophenotype of Hodgkin lymphoma, even when not in transformation. The presence of these Hodgkin and Reed-Sternberg cells in CLL can cause a diagnostic dilemma.