Fibrous Dysplasia Presenting as a Cold Spot in 18F-FLT PET/CT Imaging. (June 2016)

• Record Type: Journal Article
• Authors: Rehak, Zdenek; Bencsikova, Beatrix; Zambo, Iva; Kazda, Tomas
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 6(2016)
• Publication Date: 2016-06
• Subjects: fibrous dysplasia -- FLT -- thymidine -- PET/CT -- bone tumor; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001209
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Fibrous dysplasia (FD) is a benign bone lesion in which normal bone marrow is replaced by fibro-osseous tissue. The usual high fluorodeoxyglucose ( 18 F-FDG) uptake in FD may lead to the misdiagnosis of bone malignancy. Herein, we describe the case of a 42-year old man with histologically verified FD of the pubic bone, which has been subsequently examined during follow-up for rectal cancer, using both 18 F-FDG and fluorothymidine ( 18 F-FLT) PET/CT imaging. The FD lesion was characterized by a high uptake of 18 F-FDG (hot spot) but very low uptake of 18 F-FLT (cold spot) as compared with the contralateral unaffected pubic bone.