Anterograde Degeneration of the Nigrostriatal Pathway Visualized by 123I-FP-CIT SPECT in a Patient With Artery of Percheron Infarction. (June 2016)

• Record Type: Journal Article
• Authors: Nakadate, Masashi; Miyamoto, Norikazu; Starkey, Jay; Toriihara, Akira; Tateishi, Ukihide
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 6(2016)
• Publication Date: 2016-06
• Subjects: 123I-FP-CIT SPECT -- vascular parkinsonism -- infarction of substantia nigra -- artery of Percheron infarction -- anterograde degeneration -- nigrostriatal pathway; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001187
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 123 I-FP-CIT SPECT is widely used for diagnosis in patients with parkinsonism. Vascular parkinsonism usually has nonspecific findings from normal uptake to radiotracer decrease in the infarcted region. Infarction of the substantia nigra has been reported as a rare cause of vascular parkinsonism. We present a case of artery of Percheron infarction involving the substantia nigra unilaterally with ipsilateral reduction of striatal uptake on 123 I-FP-CIT SPECT, suggesting anterograde degeneration of the nigrostriatal pathway. Infarction of the substantia nigra should be considered in cases of decreased striatal uptake with marked laterality on 123 I-FP-CIT SPECT.