Tissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort study. Issue 4 (June 2016)

• Record Type: Journal Article
• Authors: Dusse, Luci M.; Godoi, Lara C.; Gomes, Karina B.; Carvalho, Maria das G.; Lwaleed, Bashir A.
• Is Part Of: Blood coagulation and fibrinolysis. Volume 27:Issue 4(2016)
• Page Start: 436
• Page End: 440
• Publication Date: 2016-06
• Subjects: blood -- factor VII -- factor VIIa -- plasma -- preeclampsia -- pregnancy complications -- tissue factor -- tissue factor pathway inhibitor; Blood -- Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; Blood Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 612.115
• DOI: 10.1097/MBC.0000000000000507
• Languages: English
• ISSNs: 0957-5235

Abstract

Abstract : Previously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women ( n = 79), normotensive pregnant women ( n = 80) and women with severe P-EC ( n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women ( P < 0.01) or normotensive pregnant women ( P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women ( P < 0.01). However, no such significant trends were observed for plasma TF levels ( P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity.