Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing. (24th April 2016)

• Record Type: Journal Article
• Authors: Casadellà, Maria; Noguera-Julian, Marc; Sunpath, Henry; Gordon, Michelle; Rodriguez, Cristina; Parera, Mariona; Kuritzkes, Daniel R.; Marconi, Vincent C.; Paredes, Roger
• Is Part Of: AIDS. Volume 30:Number 7(2016)
• Page Start: 1137
• Page End: 1140
• Publication Date: 2016-04-24
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001033
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : In a South African cohort of participants living with HIV developing virological failure on first-line tenofovir disoproxyl fumarate (TDF)-based regimens, at least 70% of participants demonstrated TDF resistance according to combined Sanger and MiSeq genotyping. Sanger sequencing missed the K65R mutation in 30% of samples. Unless HIV genotyping is available to closely monitor epidemiological HIV resistance to TDF, its efficacy as second-line therapy will be greatly compromised.