DOUBLE RETINAL PIGMENT EPITHELIUM TEARS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Mouallem, Alexandra; Sarraf, David; Chen, Xuejing; Capuano, Vittorio; Souied, Eric H.; Querques, Giuseppe
• Is Part Of: Retina. Volume 36:Issue 11(2016:Nov.)
• Publication Date: 2016-11
• Subjects: anti-VEGF -- fluorescein angiography -- fundus autofluorescence -- neovascular age-related macular degeneration -- retinal pigment epithelium tear -- spectral-domain optical coherence tomography -- vascularized pigment epithelium detachment; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000001062
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To describe the occurrence and treatment outcomes of double retinal pigment epithelium (RPE) tears in neovascular age-related macular degeneration and to elucidate the mechanism of tear development by means of multimodal imaging analysis. Methods: Fundus autofluorescence, spectral-domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography were retrospectively studied before and after the occurrence of first and second RPE tears and at the final visit. Results: Twelve eyes of 10 patients that developed double RPE tears, either simultaneously (6 eyes) or at variable intervals after repeated intravitreal anti–vascular endothelial growth factor administration (6 eyes), were included. First RPE tears developed after a mean of 4.5 ± 2.7 anti–vascular endothelial growth factor injections; second RPE tears developed after a mean of 7.1 ± 5.2 anti–vascular endothelial growth factor injections. Mean best-corrected visual acuity was 20/63 at baseline evaluation, 20/76 after occurrence of first tear, 20/90 after occurrence of second tear, and 20/95 at final visit ( P > 0.05 for all). Multimodal imaging revealed in all cases a Type 1 neovascular lesion adherent to the posterior surface of the RPE and spanning a significant portion of the pigment epithelium detachment with variable orientation; after development of double tears, the RPE seemed retracted on both borders of the neovascular network. Conclusion: Double RPE tears may occur on opposite sides of a vascularized pigment epithelium detachment, in eyes with neovascular age-related macular degeneration after anti–vascular endothelial growth factor therapy, because of neovascular contraction of a Type 1 neovascular complex, adherent to the posterior surface of the RPE and spanning a significant portion of the pigment epithelium detachment area. Abstract : Double retinal pigment epithelium tears may develop in eyes with vascularized pigment epithelium detachment either simultaneously or at variable intervals after repeated intravitreal anti–vascular endothelial growth factor administration. Double retinal pigment epithelium tears may occur because of neovascular contraction on each side of a Type 1 neovascular lesion adherent to the posterior surface of the retinal pigment epithelium spanning a significant portion of the pigment epithelium detachment area.