Putative Physiopathological Explanation for the "Sock Sign" in Bone Scans. (September 2016)

• Record Type: Journal Article
• Authors: de Vaugelade, Carole; Pinaquy, Jean-Baptiste; Fernandez, Philippe; Bordenave, Laurence; Hindie, Elif; Zanotti-Fregonara, Paolo
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 9(2016)
• Publication Date: 2016-09
• Subjects: bone scan -- extravasation -- sock sign; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001255
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Four patients were referred to our department to undergo a bone scan for suspected reflex sympathetic dystrophy in the upper limbs. After 99m TC-HMDP injection in the foot, they developed a "sock sign, " defined by highly increased uptake in the injected lower limb. The sock sign has been previously described in only 1 case in the literature and attributed to intra-arterial injection. Our images suggest that the sock sign might instead be the consequence of tracer extravasation at the injection site.