A systematic review of current studies in patients with familial hypercholesterolemia by use of national familial hypercholesterolemia registries. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Mundal, Liv; Retterst⊘l, Kjetil
• Is Part Of: Current opinion in lipidology. Volume 27:Issue 4(2016:Aug.)
• Page Start: 388
• Page End: 397
• Publication Date: 2016-08
• Subjects: cardiovascular disease -- familial hypercholesterolemia -- morbidity -- mortality -- registry studies; Lipids -- Periodicals; 572.574
• DOI: 10.1097/MOL.0000000000000300
• Languages: English
• ISSNs: 1473-6535

Abstract

Abstract : Purpose of review: More than 25 million are expected to have familial hypercholesterolemia worldwide. The risk of cardiovascular disease (CVD) in familial hypercholesterolemia is not clear and register studies represent a valuable tool to get such data, which will be discussed in the present paper. Recent finding: A systematic review of current familial hypercholesterolemia studies, by use of National familial hypercholesterolemia registries was performed from 1980 to 2016. This review shows that familial hypercholesterolemia patients have a high prevalence of CVD also in the time period after statins became available. The patient group does not reach recommended target values for lipids, and have a significantly higher CVD mortality as compared with the general population according to age and sex. Summary: The review underscores the importance of establishing National familial hypercholesterolemia registries with complete datasets on familial hypercholesterolemia patients to improve early diagnostics, therapeutics and long-term follow-up to prevent the premature CVD events and deaths in this patient group.