End-Stage Renal Disease From Cast Nephropathy in a Teenager With Neuroendocrine Carcinoma. Issue 5 (July 2016)

• Record Type: Journal Article
• Authors: Butani, Lavjay; Ducore, Jonathan
• Is Part Of: Journal of pediatric hematology/oncology. Volume 38:Issue 5(2016)
• Publication Date: 2016-07
• Subjects: end-stage renal disease -- neuroendocrine tumor -- cast nephropathy; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000556
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Cast nephropathy is the most common manifestation of renal injury in patients with multiple myeloma but is rarely reported in other conditions. We are reporting our experience in caring for a teenager with a metastatic neuroendocrine carcinoma who developed rapidly progressive kidney injury that advanced to end-stage renal disease. On renal biopsy extensive tubular necrosis and intratubular eosinophilic casts were noted. This previously unreported finding should prompt oncologists to closely monitor for such a complication in patients with secretory tumors. Whether early plasmapheresis could be of benefit, as has been tried in multiple myeloma, remains to be determined.