Voriconazole-Loaded Nanostructured Lipid Carriers for Ocular Drug Delivery. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Andrade, Lígia M.; Rocha, Kamilla A. D.; De Sá, Fernando A. P.; Marreto, Ricardo N.; Lima, Eliana M.; Gratieri, Tais; Taveira, Stephânia F.
• Is Part Of: Cornea. Volume 35:Issue 6(2016)
• Publication Date: 2016-06
• Subjects: nanostructured lipid carriers -- voriconazole -- ocular delivery; Cornea -- Periodicals; Cornea -- Periodicals; Cornée -- Périodiques; 617.719
• DOI: 10.1097/ICO.0000000000000825
• Languages: English
• ISSNs: 0277-3740

Abstract

Abstract : Purpose: To design and evaluate the potential of a topical delivery system for ocular administration of voriconazole, based on cationic nanostructured lipid carriers (NLCs). Methods: NLC dispersions composed of glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, and cetylpyridinium chloride were obtained and characterized. Ex vivo permeations experiments were performed to evaluate their drug delivery potential. Results: NLCs presented a mean diameter of 250.2 ± 03.1 nm, narrow polydispersity index (0.288 ± 0.03), positive zeta potential (31.22 ± 3.8 mV), and over 75% encapsulation efficiency. Ex vivo ocular experiments proved that NLCs were able to deliver therapeutically relevant drug amounts to the cornea after only 30 minutes (13.88 ± 0.24 μg/cm 2 ). Conclusions: The formulation was nonexpensive, easy to prepare, and composed of well-tolerated and accepted excipients. Further in vivo experiments are necessary to confirm the improved performance and tolerability of the formulation.