The prognostic value of autoantibodies against β1-adrenoceptor and cardiac troponin-I for clinical outcomes in STEMI. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Fan, Yan; Chen, Yuewu; Wan, Zhaofei; Zhou, Dong; Ma, Aiqun
• Is Part Of: Journal of cardiovascular medicine. Volume 18:Issue 1(2017:Jan.)
• Page Start: 34
• Page End: 41
• Publication Date: 2017-01
• Subjects: β1-adrenoceptor autoantibody -- autoantibody against cardiac troponin-I -- cardiovascular events -- left ventricular remodeling -- ST-elevation myocardial infarction; Cardiology -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cardiology -- Periodicals; Cardiovascular Diseases -- Periodicals; 616.1005
• DOI: 10.2459/JCM.0000000000000273
• Languages: English
• ISSNs: 1558-2027

Abstract

Abstract : Aims: The prevalence and potential role of autoantibodies against the β1-adrenoceptor autoantibody (β1-aab) and cardiac troponin-I (anti-cTnI) in patients with ST-elevation myocardial infarction (STEMI) are unknown. The aim of this study is to test whether β1-aab and anti-cTnI are prevalent in STEMI patients and to investigate their prognostic value for left ventricular remodeling and clinical outcomes in STEMI patients. Methods: This study included 491 patients with first STEMI at two centers. Serum samples were obtained. β1-aab and anti-cTnI were detected by enzyme-linked immunoabsorbent assay. Echocardiographic assessments were performed at admission and following 1 year. The major adverse cardiovascular events (MACEs) were evaluated during a median follow-up period of 37 months. Results: The positive rates of β1-aab and anti-cTnI in STEMI patients were 39.1 and 19.1%, respectively. The extent of left ventricular remodeling correlated with the presence of β1-aab and/or anti-cTnI (double positive > single positive > double negative). Logistic regression revealed that both β1-aab [odds ratio (OR) 2.298, 95% confidence interval (CI) 1.561–3.384, P < 0.001] and anti-cTnI (OR 2.389, 95% CI 1.460–3.909, P = 0.001) were predictive of left ventricular remodeling. Cox proportional-hazard regression revealed that β1-aab, but not anti-cTnI, was strongly predictive of MACEs (hazard ratio 1.802, 95% CI 1.301–2.496, P < 0.001). Conclusion: β1-aab and anti-cTnI were prevalent in STEMI patients. Both β1-aab and anti-cTnI were independent predictors of left ventricular remodeling, whereas only β1-aab was an independent predictor of MACEs. Our findings suggest that β1-aab and anti-cTnI may actively participate in the process of left ventricular remodeling after STEMI.