A Randomized Controlled Trial of Vagus Nerve-preserving Distal Gastrectomy Versus Conventional Distal Gastrectomy for Postoperative Quality of Life in Early Stage Gastric Cancer Patients. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Kim, Su Mi; Cho, Juhee; Kang, Danbee; Oh, Seung Jong; Kim, Ae Ran; Sohn, Tae Sung; Noh, Jae Hyoung; Kim, Sung
• Is Part Of: Annals of surgery. Volume 263:Issue 6(2016:Jun.)
• Page Start: 1079
• Page End: 1084
• Publication Date: 2016-06
• Subjects: appetite loss -- diarrhea -- gastrectomy -- gastric cancer -- vagus nerve; Surgery -- Periodicals; 617.005
• DOI: 10.1097/SLA.0000000000001565
• Languages: English
• ISSNs: 0003-4932

Abstract

Abstract : Supplemental Digital Content is available in the text Abstract : Objective: To compare the postoperative quality of life of vagus nerve preserving distal gastrectomy (VPG) vs conventional distal gastrectomy (CG) in patients with early-stage gastric cancer. Design: Randomized controlled clinical trial. Setting: Large tertiary comprehensive cancer center in Korea. Participants: One hundred sixty-three patients with early gastric cancer 18 years of age or older expected to undergo curative gastric resection. Intervention: Patients were randomized 1:1 to VPG (n = 85) or CG (n = 78). Main outcome measures: European Organization for Research and Treatment of Cancer (EORTC) gastric module (STO22). Results: Patients assigned to VPG showed less diarrhea 3 and 12 months after surgery ( P = 0.040 and 0.048, respectively) and less appetite loss at 12 months ( P = 0.011) compared with those assigned to CG. In both groups, fatigue, anxiety, eating restriction, and body image deteriorated at 3 months after surgery and did not regain baseline levels 12 months after surgery. There were no significant differences between the 2 groups in cancer recurrence and death over 5 years of follow-up. Conclusions: Early gastric cancer patients undergoing VPG reported significantly less diarrhea and appetite loss at 12 months postsurgery compared with those undergoing CG, with no differences in long-term clinical outcomes. VPG may improve the quality of life after gastrectomy in early gastric cancer patients compared with CG.