68Ga-NODAGA-RGDyK PET/CT Imaging in Esophageal Cancer: First-in-Human Imaging. (November 2016)

• Record Type: Journal Article
• Authors: Van Der Gucht, Axel; Pomoni, Anastasia; Jreige, Mario; Allemann, Pierre; Prior, John O.
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 11(2016)
• Publication Date: 2016-11
• Subjects: 68Ga-NODAGA-RGDyK -- FDG -- PET/CT -- esophageal cancer -- angiogenesis; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001365
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 68 Ga-NODAGA-RGDyK(cyclic) and FDG PET/CT were performed in a 39-year-old man for the work-up of a moderately differentiated carcinoma of the gastro-esophageal junction within a clinical study protocol. Although FDG PET images showed intense, diffuse hypermetabolic lesion activity, NODAGA-RGDyK illustrated the neo-angiogenesis process with tracer uptake clearly localized in non–FDG-avid perilesional structures. Neo-angiogenesis is characterized by αν β3 integrin expression at the lesion surface of newly formed vessels. This case supports evidence that angiogenesis imaging might therefore be a crucial step in early disease identification and localization, metastatization potential, and in monitoring the efficacy of antiangiogenic therapies.