Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy. (June 2016)

• Record Type: Journal Article
• Authors: Sato, Kenichiro; Hida, Ayumi; Kameyama, Masashi; Morooka, Miyako; Takeuchi, Sousuke
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 6(2016)
• Publication Date: 2016-06
• Subjects: diabetic chorea -- 123I ioflupane -- dopamine transporter SPECT -- 18F FDG PET -- 123I MIBG scintigraphy; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001202
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, 18 F FDG PET, 99m Tc ethylcysteinate dimer (ECD) SPECT, and 123 I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced 123 I ioflupane binding in the bilateral striatum. 18 F FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. 99m Tc ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. 123 I MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea.