Brief Report: Apparent Antiretroviral Overadherence by Pill Count is Associated With HIV Treatment Failure in Adolescents. (15th August 2016)

• Record Type: Journal Article
• Authors: Okatch, Harriet; Beiter, Kaylin; Eby, Jessica; Chapman, Jennifer; Marukutira, Tafireyi; Tshume, Ontibile; Matshaba, Mogomotsi; Anabwani, Gabriel M.; Gross, Robert; Lowenthal, Elizabeth
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 72:Number 5(2016)
• Publication Date: 2016-08-15
• Subjects: adolescents -- adherence monitoring -- resource-limited settings -- antiretroviral therapy; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000994
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Pill counts with calculated adherence percentages are used in many settings to monitor adherence, but can be undermined by patients discarding pills to hide nonadherence. Pill counts suggesting that >100% of prescribed doses were taken can signal "pill dumping." We defined "overadherence" among a cohort of 300 HIV-infected adolescents as having greater than one-third of pill counts with >100% adherence during a year of follow-up. Apparent overadherence was more common in those with virologic failure than in those with suppressed viral loads (33% vs 13%, χ 2 P = 0.001). Pill count adherence repeatedly >100% may identify HIV-infected adolescents at increased risk of treatment failure. Abstract : Supplemental Digital Content is Available in the Text.