Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. (1st January 2017)

• Record Type: Journal Article
• Authors: Eshleman, Susan H.; Hudelson, Sarah E.; Redd, Andrew D.; Swanstrom, Ronald; Ou, San-San; Zhang, Xinyi Cindy; Ping, Li-Hua; Piwowar-Manning, Estelle; Porcella, Stephen F.; Sievers, Matthew F.; Martens, Craig A.; Bruno, Daniel; Dukhovlinova, Elena; McCauley, Marybeth; Gamble, Theresa; Fogel, Jessica M.; Sabin, Devin; Quinn, Thomas C.; Gunde, Laurence; Maliwichi, Madalitso; Nhando, Nehemiah; Akelo, Victor; Moyo, Sikhulile; Panchia, Ravindre; Kumarasamy, Nagalingeswaran; Chotirosniramit, Nuntisa; Melo, Marineide Gonçalves de; Pilotto, Jose; Grinsztejn, Beatriz; Mayer, Kenneth; Chen, Ying Q.; Hughes, James P.; Cohen, Myron S.;
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 74:Number 1(2017)
• Page Start: 112
• Page End: 116
• Publication Date: 2017-01-01
• Subjects: HIV-1 -- serodiscordant couples -- partner -- transmission -- linkage -- HPTN 052; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000001158
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Supplemental Digital Content is Available in the Text. Abstract: HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index–partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.