In-utero exposure to nelfinavir-ethyl methyl sulfone. (13th November 2016)

• Record Type: Journal Article
• Authors: Hleyhel, Mira; Goujon, Stéphanie; Sibiude, Jeanne; Blanche, Stéphane; Warszawski, Josiane
• Is Part Of: AIDS. Volume 30:Number 17(2016)
• Publication Date: 2016-11-13
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001254
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : Ethyl methyl sulfone contained in nelfinavir between 2007 and 2008 accidentally exposed embryos and fetuses to a powerful mutagen. We report data for 101 HIV-uninfected children exposed in utero included in the French prospective national cohort. The incidence of malformation was similar to that in the cohort as a whole with different drug exposures; no children had developed cancer after 9 years of follow-up.