Clonality of localized and metastatic prostate cancer. Issue 3 (May 2016)

• Record Type: Journal Article
• Authors: Boutros, Paul C.; Fraser, Michael; van der Kwast, Theodorus; Bristow, Robert G.
• Is Part Of: Current opinion in urology. Volume 26:Issue 3(2016:May)
• Page Start: 219
• Page End: 224
• Publication Date: 2016-05
• Subjects: prostate cancer -- spatial genomic heterogeneity -- tumour evolution -- tumour subclonality -- whole genome sequencing; Urology -- Periodicals; Review Literature -- Bibliography; Review Literature -- Periodicals; Male Urogenital Diseases -- Bibliography; Male Urogenital Diseases -- Periodicals; Female Urogenital Diseases -- Bibliography; Female Urogenital Diseases -- Periodicals; Urologic Diseases -- Bibliography; Urologic Diseases -- Periodicals; Periodicals; 616.6005
• DOI: 10.1097/MOU.0000000000000279
• Languages: English
• ISSNs: 1473-6586

Abstract

Abstract : Purpose of review: The influence of the long life-history of prostate cancer on the temporal and spatial variability of the tumour genome is now being elucidated. Multiregion sequencing to identify spatio-genomic differences in prostate tumour mutation profiles combined with computational approaches can map the evolution and transit of tumour cells throughout an individual patient. Recent findings: A series of recent studies have demonstrated that a prostate tumour is often composed of different subclones, with varying genetic similarity. As such, a single biopsy specimen may be insufficient to make accurate clinical predictions from molecular biomarkers, greatly complicating the application of biopsy-based tools for precision medicine. In addition, subclones that arise outside of the primary tumour can seed new metastases and circulate between sites within a patient. Summary: The mutational complexity of multiple tumour clones within the same individual, which respond differently to specific treatments, suggests the need for multimodal interventions.