The miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency. Issue 9 (September 2016)

• Record Type: Journal Article
• Authors: Pan, Hong; Chen, Beili; Wang, Jing; Wang, Xi; Hu, Ping; Wu, Shinan; Liu, Yunyun; Xu, Zuying; Zhang, Wei; Wang, Binbin; Cao, Yunxia
• Is Part Of: Menopause. Volume 23:Issue 9(2016)
• Publication Date: 2016-09
• Subjects: miR-449b -- Polymorphism -- Premature ovarian insufficiency; Menopause -- Periodicals; 618.175005
• DOI: 10.1097/GME.0000000000000659
• Languages: English
• ISSNs: 1072-3714

Abstract

Abstract: Objective: To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis. Methods: From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry. Results: Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI. Conclusions: Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.